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Antimicrobial Agents and Chemotherapy, August 2009, p. 3565-3568, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.00102-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Enhancement of Human Immunodeficiency Virus Type 1 Replication Is Not Intrinsic to All Polyanion-Based Microbicides {triangledown}

Secondo Sonza,1,2 Adam Johnson,1 David Tyssen,1 Tim Spelman,1 Gareth R. Lewis,3 Jeremy R. A. Paull,3 and Gilda Tachedjian1,2,4*

Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria 3004, Australia,1 Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia,2 Starpharma Pty Ltd., Melbourne, Victoria 3004, Australia,3 Department of Medicine, Monash University, Melbourne, Victoria 3004, Australia4

Received 23 January 2009/ Returned for modification 13 March 2009/ Accepted 3 June 2009

Polyanion-based microbicides have been developed to prevent the sexual transmission of human immunodeficiency virus (HIV). Recent data suggest that polyanions have the capacity to enhance HIV type 1 (HIV-1) replication at threshold antiviral concentrations. Evaluation of the microbicide candidates SPL7013 and PRO 2000 revealed no specific enhancement of two CCR5 HIV-1 strains in human peripheral blood mononuclear cells compared to enfuvirtide (Fuzeon). The enhancement effect is likely to be a function of the assay conditions and is not an intrinsic property of these polyanions.

* Corresponding author. Mailing address: Molecular Interactions Group, Centre for Virology, The Macfarlane Burnet Institute for Medical Research and Public Health, GPO Box 2284, Melbourne, Victoria 3001, Australia. Phone: 61 3 9282 2256. Fax: 61 3 9282 2100. E-mail: gildat{at}burnet.edu.au

{triangledown} Published ahead of print on 15 June 2009.

Antimicrobial Agents and Chemotherapy, August 2009, p. 3565-3568, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.00102-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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