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Antimicrobial Agents and Chemotherapy, August 2009, p. 3582-3584, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.01574-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

oqxAB Encoding a Multidrug Efflux Pump in Human Clinical Isolates of Enterobacteriaceae{triangledown}

Hong Bin Kim,1,2,3 Minghua Wang,3,4 Chi Hye Park,3 Eui-Chong Kim,5 George A. Jacoby,6 and David C. Hooper3*

Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea,1 Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea,2 Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts,3 Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China,4 Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea,5 Lahey Clinic, Burlington, Massachusetts6

Received 26 November 2008/ Returned for modification 26 December 2008/ Accepted 30 May 2009

The genes for multidrug efflux pump OqxAB, which is active on fluoroquinolones, were found in human clinical isolates on a plasmid in Escherichia coli and on the chromosome of Klebsiella pneumoniae. IS26-like sequences flanked the plasmid-mediated oqxAB genes, suggesting that they had been mobilized as part of a composite transposon.

* Corresponding author. Mailing address: Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114-2696. Phone: (617) 726-3812. Fax: (617) 726-7416. E-mail: dhooper{at}partners.org

{triangledown} Published ahead of print on 15 June 2009.

Antimicrobial Agents and Chemotherapy, August 2009, p. 3582-3584, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.01574-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Strahilevitz, J., Jacoby, G. A., Hooper, D. C., Robicsek, A. (2009). Plasmid-Mediated Quinolone Resistance: a Multifaceted Threat. Clin. Microbiol. Rev. 22: 664-689 [Abstract] [Full Text]  


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