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Antimicrobial Agents and Chemotherapy, August 2009, p. 3585-3588, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.00293-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Efficacy of Triazoles in a Murine Disseminated Infection by Candida krusei{triangledown}

Marçal Mariné, F. Javier Pastor, Carolina Serena, and Josep Guarro*

Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain

Received 4 March 2009/ Returned for modification 15 April 2009/ Accepted 14 May 2009

We evaluated the efficacies of posaconazole and voriconazole in comparison with that of amphotericin B in a systemic murine infection by Candida krusei. Posaconazole at 50 mg/kg/day and voriconazole at 40 and 60 mg/kg/day prolonged survival and reduced the fungal tissue burden in the kidneys of mice similarly to amphotericin B at 1.5 mg/kg/day and liposomal amphotericin B at 10 mg/kg/day. None of the treatments tested completely resolved the infection.

* Corresponding author. Mailing address: Unitat de Microbiologia, Facultat de Medicina, IISPV, Universitat Rovira i Virgili, Carrer Sant Llorenç 21, 43201 Reus, Spain. Phone: 34-977-759359. Fax: 34-977-759322. E-mail: josep.guarro{at}urv.cat

{triangledown} Published ahead of print on 26 May 2009.

Antimicrobial Agents and Chemotherapy, August 2009, p. 3585-3588, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.00293-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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