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Antimicrobial Agents and Chemotherapy, August 2009, p. 3589-3591, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.00570-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Novel ABC Transporter Gene, vga(C), Located on a Multiresistance Plasmid from a Porcine Methicillin-Resistant Staphylococcus aureus ST398 Strain {triangledown}

Kristina Kadlec and Stefan Schwarz*

Institute of Farm Animal Genetics, Friedrich-Loeffler-Institute (FLI), Höltystr. 10, 31535 Neustadt-Mariensee, Germany

Received 28 April 2009/ Accepted 15 May 2009

A novel ABC transporter gene, vga(C), was identified on the 14,365-bp multiresistance plasmid pKKS825 in a porcine methicillin (meticillin)-resistant Staphylococcus aureus isolate of sequence type 398. The vga(C) gene encodes a 523-amino-acid protein which confers resistance not only to streptogramin A antibiotics but also to lincosamides and pleuromutilins. Plasmid pKKS825 also carries the resistance genes aadD, tet(L), and dfrK, which may enable the coselection of vga(C) under selective pressure by kanamycin/neomycin, tetracyclines, and trimethoprim.

* Corresponding author. Mailing address: Institute of Farm Animal Genetics, Friedrich-Loeffler-Institute (FLI), Höltystr. 10, 31535 Neustadt-Mariensee, Germany. Phone: 49-5034-871-241. Fax: 49-5034-871-246. E-mail: stefan.schwarz{at}fli.bund.de

{triangledown} Published ahead of print on 26 May 2009.

Antimicrobial Agents and Chemotherapy, August 2009, p. 3589-3591, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.00570-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Kadlec, K., Ehricht, R., Monecke, S., Steinacker, U., Kaspar, H., Mankertz, J., Schwarz, S. (2009). Diversity of antimicrobial resistance pheno- and genotypes of methicillin-resistant Staphylococcus aureus ST398 from diseased swine. J Antimicrob Chemother 64: 1156-1164 [Abstract] [Full Text]  


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