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Antimicrobial Agents and Chemotherapy, August 2009, p. 3592-3594, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.00471-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Evaluation of Artemisone Combinations in Aotus Monkeys Infected with Plasmodium falciparum{triangledown}

Nicanor Obaldia III,1 Barbara M. Kotecka,2 Michael D. Edstein,2 Richard K. Haynes,3 Burkhard Fugmann,4 Dennis E. Kyle,2 and Karl H. Rieckmann2*

Tropical Medicine Research, Malaria Drug and Vaccine Evaluation Center/Gorgas Memorial Institute of Health Studies, Panama, Panama,1 Australian Army Malaria Institute, Brisbane, Australia,2 Department of Chemistry, Open Laboratory of Chemical Biology, Institute of Molecular Technology for Drug Discovery and Synthesis, Hong Kong University of Science and Technology, Kowloon, Hong Kong,3 Bayer Innovation, Düsseldorf, Germany4

Received 9 April 2009/ Returned for modification 11 May 2009/ Accepted 1 June 2009

Artemisone (single oral dose, 10 mg/kg of body weight) cured nonimmune Aotus monkeys of their Plasmodium falciparum infections when combined with mefloquine (single oral dose, 5 and 10 mg/kg but not 2.5 mg/kg). In combination with amodiaquine (20 mg/kg/day), artemisone (10 mg/kg/day) given orally for 3 days cured all infected monkeys. Three days of treatment with artemisone (30 mg/kg/day) and clindamycin (100 mg/kg/day) was also curative.

* Corresponding author. Mailing address: Australian Army Malaria Institute, Enoggera, Brisbane QLD 4051, Australia. Phone: 61-7-54928154. Fax: 61-7-33324800. E-mail: krieckmann{at}iprimus.com.au

{triangledown} Published ahead of print on 8 June 2009.

Antimicrobial Agents and Chemotherapy, August 2009, p. 3592-3594, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.00471-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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