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Antimicrobial Agents and Chemotherapy, August 2009, p. 3595-3598, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.01623-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Nukacin ISK-1, a Bacteriostatic Lantibiotic {triangledown}

Sikder M. Asaduzzaman,1 Jun-ichi Nagao,2 Hiroshi Iida,3 Takeshi Zendo,1 Jiro Nakayama,1 and Kenji Sonomoto1,4*

Laboratory of Microbial Technology, Division of Microbial Science and Technology, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan,1 Section of Infection Biology, Department of Functional Bioscience, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka 814-0193, Japan,2 Department of Applied Genetic and Pest Management, Faculty of Agriculture, Graduate School, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan,3 Laboratory of Functional Food Design, Department of Functional Metabolic Design, Bio-Architecture Center, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan4

Received 10 December 2008/ Returned for modification 5 April 2009/ Accepted 1 June 2009

We determined the mode of action of nukacin ISK-1. It did not cause membrane potential dissipation or the efflux of ATP or K+ ions from the cells of a sensitive bacterial strain; however, it blocked the membrane depolarization activity of nisin. Nukacin ISK-1-treated cells had single arrangements of cells without the formation of a complete septum. A remarkable reduction in cell wall width was also observed, but cytoplasmic content was unaffected. We concluded that nukacin ISK-1 is bacteriostatic.

* Corresponding author. Mailing address: Laboratory of Microbial Technology, Division of Microbial Science and Technology, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan. Phone and fax: 81-92-642-3019. E-mail: sonomoto{at}agr.kyushu-u.ac.jp

{triangledown} Published ahead of print on 8 June 2009.

Antimicrobial Agents and Chemotherapy, August 2009, p. 3595-3598, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.01623-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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