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Antimicrobial Agents and Chemotherapy, September 2009, p. 3989-3991, Vol. 53, No. 9
0066-4804/09/$08.00+0     doi:10.1128/AAC.00722-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

The Diarylquinoline R207910 Is Bactericidal against Mycobacterium leprae in Mice at Low Dose and Administered Intermittently{triangledown}

Robert Gelber,1* Koen Andries,2 Rose Maria D. Paredes,1 Cora Evelyn S. Andaya,1 and Jasmin Burgos1

Leonard Wood Memorial, Cebu, the Philippines,1 Department of Antimicrobial Research, Tibotec BVBA, Johnson & Johnson, Beerse, Belgium2

Received 28 May 2009/ Returned for modification 12 June 2009/ Accepted 5 July 2009

The diarylquinoline R207910 is profoundly bactericidal in a murine model of tuberculosis. Previously, R207910 was also found to be bactericidal for Mycobacterium leprae-infected mice during lag phase. Herein we evaluate the bactericidal efficacy of R207910 (1 to 120 mg/kg of body weight) when administered five times weekly, once weekly, and once monthly during logarithmic multiplication of M. leprae organisms. All treatments were found to be bactericidal, suggesting that both low and intermittent dosing with R207910 holds promise for leprosy patients.

* Corresponding author. Present address: 220 Scenic Avenue, San Anselmo, CA 94960. Phone: (415) 454-8765. Fax: (415) 454-8191. E-mail: ikgelber{at}hotmail.com

{triangledown} Published ahead of print on 13 July 2009.

Antimicrobial Agents and Chemotherapy, September 2009, p. 3989-3991, Vol. 53, No. 9
0066-4804/09/$08.00+0     doi:10.1128/AAC.00722-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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