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Antimicrobial Agents and Chemotherapy, September 2009, p. 3996-4001, Vol. 53, No. 9
0066-4804/09/$08.00+0     doi:10.1128/AAC.00908-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of Telavancin and Six Comparator Agents against Anaerobic Bacterial Isolates{triangledown}

Sydney M. Finegold,1,3,4* Mauricio Bolanos,2 Paula H. Sumannen,2 and Denise R. Molitoris2

Medical,1 Research Services, Veterans Administration Greater Los Angeles Healthcare System, and Departments of,2 Medicine,3 Microbiology, Immunology and Molecular Genetics, UCLA School of Medicine, Los Angeles, California4

Received 8 July 2008/ Returned for modification 2 August 2008/ Accepted 28 June 2009

The antimicrobial activities of telavancin and six comparators were evaluated against 460 isolates of anaerobic bacteria. Telavancin demonstrated excellent activity against gram-positive anaerobes (MIC90, 2 µg/ml) and was the most potent agent tested against Clostridium difficile (MIC90, 0.25 µg/ml). As expected, gram-negative isolates were not inhibited by telavancin.

* Corresponding author. Mailing address: Infectious Diseases Section (111F), VA Medical Center, West Los Angeles, 11301 Wilshire Boulevard, Los Angeles, CA 90073. Phone: (310) 268-3678. Fax: (310) 268-3594. E-mail: sidfinegol{at}aol.com

{triangledown} Published ahead of print on 6 July 2009.

Antimicrobial Agents and Chemotherapy, September 2009, p. 3996-4001, Vol. 53, No. 9
0066-4804/09/$08.00+0     doi:10.1128/AAC.00908-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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