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Antimicrobial Agents and Chemotherapy, September 2009, p. 4002-4006, Vol. 53, No. 9
0066-4804/09/$08.00+0     doi:10.1128/AAC.00753-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Genetic Context of Plasmid-Carried blaCMY-2-Like Genes in Enterobacteriaceae{triangledown} ,{dagger}

C. Verdet,1,2 V. Gautier,2 E. Chachaty,3 E. Ronco,4 N. Hidri,5 D. Decré,2 and G. Arlet1,2*

AP-HP, Hôpital Tenon, Service de Bactériologie, Paris, France,1 Université Paris VI, UPRES EA 2392, UFR de Médecine Pierre et Marie Curie, Paris, France,2 Service de Microbiologie Médicale, Institut Gustave Roussy, Villejuif, France,3 AP-HP, Hôpital Raymond Poincaré, Laboratoire de Microbiologie, Garches, France,4 Laboratoire de Biologie, Centre Hospitalier de Lagny-Marne-la-Vallée, Lagny, France5

Received 9 June 2008/ Returned for modification 23 August 2008/ Accepted 4 July 2009

Analysis of 15 European clinical Enterobacteriaceae isolates showed that differences in the genetic context of blaCMY-2-like genes reflected the replicon type, usually IncA/C or IncI1. These blaCMY-2 loci may originate from the same ISEcp1-mediated mobilization from the Citrobacter freundii chromosome as structures described in earlier studies.

* Corresponding author. Mailing address: AP-HP, Hôpital Tenon, Service de Bactériologie, 4 rue de la Chine, Paris 75970 Cedex 20, France. Phone: 33 1 56 01 70 18. Fax: 33 1 56 01 61 08. E-mail: guillaume.arlet{at}tnn.aphp.fr

{triangledown} Published ahead of print on 13 July 2009.

{dagger} Supplemental material for this article may be found at http://aac.asm.org/.

Antimicrobial Agents and Chemotherapy, September 2009, p. 4002-4006, Vol. 53, No. 9
0066-4804/09/$08.00+0     doi:10.1128/AAC.00753-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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