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Antimicrobial Agents and Chemotherapy, September 2009, p. 4007-4009, Vol. 53, No. 9
0066-4804/09/$08.00+0     doi:10.1128/AAC.01633-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Influence of Recombination on Development of Mutational Resistance to Linezolid in Enterococcus faecalis JH2-2{triangledown}

Leyla Boumghar-Bourtchaï,1 Anne Dhalluin,1,3 Brigitte Malbruny,1,2 Sébastien Galopin,1 and Roland Leclercq1,2*

EA 2128 Interactions Hôte et Microorganismes des Épithéliums, Université de Caen, Caen,1 Service de Microbiologie CHU Côte de Nacre, Caen,2 UFR des Sciences Pharmaceutiques, Université de Caen, Caen, France3

Received 11 December 2008/ Returned for modification 13 March 2009/ Accepted 12 June 2009

We compared the propensities of Enterococcus faecalis JH2-2 and of the recombination-deficient JH2-2 recA strain to develop mutational resistance to linezolid. In both organisms, a mutation in a single rrl copy conferred resistance to linezolid. Delay in acquisition of the mutation by other rrl copies in JH2-2 recA showed that gene conversion contributed to the acquisition of resistance.

* Corresponding author. Mailing address: CHU de Caen, Service de Microbiologie, avenue Côte de Nacre, 14033 Caen cedex, France. Phone: 33231064572. Fax: 33231064573. E-mail: leclercq-r{at}chu-caen.fr

{triangledown} Published ahead of print on 22 June 2009.

Antimicrobial Agents and Chemotherapy, September 2009, p. 4007-4009, Vol. 53, No. 9
0066-4804/09/$08.00+0     doi:10.1128/AAC.01633-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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