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Antimicrobial Agents and Chemotherapy, September 2009, p. 4013-4014, Vol. 53, No. 9
0066-4804/09/$08.00+0     doi:10.1128/AAC.00584-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

CraA, a Major Facilitator Superfamily Efflux Pump Associated with Chloramphenicol Resistance in Acinetobacter baumannii{triangledown}

I. Roca,1,2,{dagger} S. Marti,1,{dagger} P. Espinal,1 P. Martínez,2 I. Gibert,2 and J. Vila1*

Department of Microbiology, Hospital Clínic, School of Medicine, University of Barcelona, IDIBAPS, Barcelona, Spain,1 Institut de Biotecnologia i de Biomedicina i Departament de Genètica i de Microbiologia, Grup de Genètica Molecular Bacteriana, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain2

Received 30 April 2009/ Returned for modification 14 June 2009/ Accepted 27 June 2009

Acinetobacter baumannii has been increasingly associated with hospital-acquired infections, and the presence of multidrug resistance strains is of great concern to clinicians. A. baumannii is thought to possess a great deal of intrinsic resistance to several antimicrobial agents, including chloramphenicol, although the mechanisms involved in such resistance are not well understood. In this work, we have identified a major facilitator superfamily efflux pump present in most A. baumannii strains, displaying strong substrate specificity toward chloramphenicol.

* Corresponding author. Mailing address: Servei de Microbiologia, Centre de Diagnòstic Biomèdic, Hospital Clínic, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain. Phone: 34 93 227 55 22. Fax: 34 93 227 93 72. E-mail: jvila{at}ub.edu

{triangledown} Published ahead of print on 6 July 2009.

{dagger} These authors equally contributed to this work.

Antimicrobial Agents and Chemotherapy, September 2009, p. 4013-4014, Vol. 53, No. 9
0066-4804/09/$08.00+0     doi:10.1128/AAC.00584-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Srinivasan, V. B., Rajamohan, G., Gebreyes, W. A. (2009). Role of AbeS, a Novel Efflux Pump of the SMR Family of Transporters, in Resistance to Antimicrobial Agents in Acinetobacter baumannii. Antimicrob. Agents Chemother. 53: 5312-5316 [Abstract] [Full Text]  


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