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Antimicrobial Agents and Chemotherapy, September 2009, p. 4028-4031, Vol. 53, No. 9
0066-4804/09/$08.00+0     doi:10.1128/AAC.00457-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Evaluation of Analogs of Reutericyclin as Prospective Candidates for Treatment of Staphylococcal Skin Infections{triangledown}

Julian G. Hurdle,* Raghunandan Yendapally, Dianqing Sun, and Richard E. Lee

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee

Received 6 April 2009/ Returned for modification 8 May 2009/ Accepted 26 June 2009

The potential for reutericyclin derivatives to be used as topical antibiotics to treat staphylococcal skin infections was investigated. All reutericyclins inhibited the growth of clinical isolates of drug-resistant Staphylococcus aureus. Unlike the standard topical agent mupirocin, most reutericyclin derivatives eradicated staphylococcal biofilms. Moreover, two compounds formulated in hydrophilic petrolatum (10%, wt/wt) were efficacious in treating S. aureus superficial skin infections in mice. These data exemplify the prospect of developing reutericyclins as new topical antibiotics.

* Corresponding author. Mailing address: Department of Pharmaceutical Sciences, Room 327 Johnson Building, 847 Monroe Ave., Memphis, TN 38163. Phone: (901) 448-7901. Fax: (901) 448-6828. E-mail: jhurdle{at}utmem.edu

{triangledown} Published ahead of print on 6 July 2009.

Antimicrobial Agents and Chemotherapy, September 2009, p. 4028-4031, Vol. 53, No. 9
0066-4804/09/$08.00+0     doi:10.1128/AAC.00457-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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