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Antimicrobial Agents and Chemotherapy, September 2009, p. 4032-4034, Vol. 53, No. 9
0066-4804/09/$08.00+0     doi:10.1128/AAC.00406-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Mosaic Penicillin-Binding Protein 2 in Neisseria gonorrhoeae Isolates Collected in 2008 in San Francisco, California{triangledown}

Mark Pandori,1,{dagger}* Pennan M. Barry,1,2,{dagger} Abel Wu,1 Alyssa Ren,1 William L. H. Whittington,3 Sally Liska,1 and Jeffrey D. Klausner1,2

San Francisco Department of Public Health, San Francisco, California 94102,1 University of California, San Francisco, California 94143,2 University of Washington, Seattle, Washington 981953

Received 26 March 2009/ Returned for modification 15 May 2009/ Accepted 11 June 2009

Using a real-time PCR assay specific for a mosaic penA allele that has been associated with oral cephalosporin resistance in Asia, 54 available Neisseria gonorrhoeae isolates collected in San Francisco, CA, from January to October 2008 were analyzed. Five isolates tested positive for the mosaic penA gene by real-time PCR. DNA sequencing revealed two mosaic penA alleles (SF-A and SF-B). Isolates with SF-A and SF-B alleles possessed elevated MICs for the oral cephalosporins cefpodoxime and cefixime.

* Corresponding author. Mailing address: San Francisco Department of Public Health Laboratory, 101 Grove Street, Room 419, San Francisco, CA 94102. Phone: (415) 554-2752. Fax: (415) 431-0651. E-mail: Mark.Pandori{at}sfdph.org

{triangledown} Published ahead of print on 22 June 2009.

{dagger} These authors contributed equally to the preparation of this report.

Antimicrobial Agents and Chemotherapy, September 2009, p. 4032-4034, Vol. 53, No. 9
0066-4804/09/$08.00+0     doi:10.1128/AAC.00406-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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