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Antimicrobial Agents and Chemotherapy, September 2009, p. 4035-4039, Vol. 53, No. 9
0066-4804/09/$08.00+0     doi:10.1128/AAC.00659-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Anidulafungin in Combination with Amphotericin B against Aspergillus fumigatus{triangledown}

Elisabetta Spreghini,1 Fiorenza Orlando,4 Alfredo Santinelli,2 Eleonora Pisa,2 Cristian Loretelli,3 Esther Manso,5 Maria Eleonara Milici,6 Giorgio Scalise,1 and Francesco Barchiesi1*

Dipartimento di Scienze Biomediche, Clinica Malattie Infettive,1 Istituto di Anatomia Patologica,2 Centro Regionale di Genetica Oncologica, Oncologia Medica, Università Politecnica delle Marche,3 Dipartimento Ricerche Gerontologiche e Geriatriche N. Masera, I.N.R.C.A. I.R.R.C.S,4 Laboratorio di Microbiologia Azienda Ospedaliero, Universitaria Ospedali Riuniti Umberto I°-Lancisi-Salesi, Ancona,5 Dipartimento di Igiene e Microbiologia D'Alessandro, Università degli Studi di Palermo, Palermo, Italy6

Received 13 May 2009/ Returned for modification 18 June 2009/ Accepted 5 July 2009

We investigated the effects of anidulafungin alone and in combination with amphotericin B against Aspergillus fumigatus. Indifference was the only type of interaction observed in vitro. Anidulafungin at 1 and 5 mg/kg of body weight/day, amphotericin B at 1 mg/kg/day, and combination therapy prolonged the survival of mice with invasive aspergillosis. Anidulafungin at 5 mg/kg/day, alone and in combination with amphotericin B, reduced the kidney fungal burden. Overall, the combination was not superior to the most active single drug.

* Corresponding author. Mailing address: Dipartimento di Scienze Biomediche, Clinica di Malattie Infettive, Università Politecnica delle Marche, Via Conca, Torrette, Ancona 60020, Italy. Phone: 39 0715963467. Fax: 39 0715963468. E-mail: f.barchiesi{at}ao-umbertoprimo.marche.it

{triangledown} Published ahead of print on 13 July 2009.

Antimicrobial Agents and Chemotherapy, September 2009, p. 4035-4039, Vol. 53, No. 9
0066-4804/09/$08.00+0     doi:10.1128/AAC.00659-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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