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Antimicrobial Agents and Chemotherapy, September 2009, p. 4040-4042, Vol. 53, No. 9
0066-4804/09/$08.00+0     doi:10.1128/AAC.00312-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Antimalarial Activity of Tigecycline, a Novel Glycylcycline Antibiotic {triangledown}

P. Starzengruber,1,2 K. Thriemer,1,2 R. Haque,3 W. A. Khan,3 H. P. Fuehrer,1,2 A. Siedl,1,2 V. Hofecker,1,2 B. Ley,1,2 W. H. Wernsdorfer,1 and H. Noedl1,2*

Department of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria,1 MARIB, Malaria Research Initiative Bandarban, Bandarban, Bangladesh,2 International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh3

Received 6 March 2009/ Returned for modification 17 May 2009/ Accepted 3 July 2009

Tigecycline is a novel glycylcycline antibiotic with a broad antibacterial spectrum. Tigecycline was tested with 66 clinical isolates of Plasmodium falciparum from Bangladesh using the histidine-rich protein 2 in vitro drug susceptibility assay. The 50% and 90% inhibitory concentrations of tigecycline were 699 (95% confidence interval, 496 to 986) and 5,905 nM (4,344 to 8,028). Tigecycline shows no activity correlation with traditional antimalarials and has substantial antimalarial activity on its own.

* Corresponding author. Mailing address: Department of Specific Prophylaxis and Tropical Medicine, Centre for Physiology and Pathophysiology, Medical University of Vienna, Kinderspitalgasse 15, A-1090 Vienna, Austria. Phone and fax: 43-1-4277-64899. E-mail: harald.noedl{at}meduniwien.ac.at

{triangledown} Published ahead of print on 13 July 2009.

Antimicrobial Agents and Chemotherapy, September 2009, p. 4040-4042, Vol. 53, No. 9
0066-4804/09/$08.00+0     doi:10.1128/AAC.00312-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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