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Antimicrobial Agents and Chemotherapy, January 2010, p. 560-562, Vol. 54, No. 1
0066-4804/10/$12.00+0     doi:10.1128/AAC.00762-09
Copyright © 2010, American Society for Microbiology. All Rights Reserved.

Nonclonal Emergence of Colistin-Resistant Klebsiella pneumoniae Isolates from Blood Samples in South Korea {triangledown}

Ji-Yoeun Suh,1 Jun Seong Son,2 Doo Ryeon Chung,3 Kyong Ran Peck,3 Kwan Soo Ko,1,4* and Jae-Hoon Song1,3*

Asian-Pacific Research Foundation for Infectious Diseases (ARFID), Seoul, South Korea,1 Kyunghee University Hospital, Seoul, South Korea,2 Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea,3 Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, South Korea4

Received 8 June 2009/ Returned for modification 8 August 2009/ Accepted 5 September 2009

In vitro activities of colistin and other drugs were tested against 221 Klebsiella pneumoniae isolates that were collected between 2006 and 2007 in nine tertiary care South Korean hospitals from patients with bacteremia. The clonality of colistin-resistant K. pneumoniae (CRKP) isolates was assessed by multilocus sequence typing (MLST). We found that 15 isolates (6.8%) were resistant to colistin. MLST showed that CRKP isolates were nonclonal, with colistin resistance in K. pneumoniae occurring independently and not by clonal spreading.

* Corresponding author. Mailing address for Kwan Soo Ko: Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon 440-746, South Korea. Phone: 82-31-299-6223. Fax: 82-31-299-6229. E-mail: ksko{at}med.skku.ac.kr. Mailing address for Jae-Hoon Song: Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea. Phone: 82-2-3410-0320. Fax: 82-2-3410-0328. E-mail: songjh{at}skku.edu

{triangledown} Published ahead of print on 14 September 2009.

Antimicrobial Agents and Chemotherapy, January 2010, p. 560-562, Vol. 54, No. 1
0066-4804/10/$12.00+0     doi:10.1128/AAC.00762-09
Copyright © 2010, American Society for Microbiology. All Rights Reserved.





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