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Antimicrob Agents Chemother. 1975 January; 7(1): 46-49
Copyright © 1975 American Society for Microbiology. All Rights Reserved.

Comparative Susceptibility of Anaerobic Bacteria to Minocycline, Doxycycline, and Tetracycline

Anthony W. Chow*, Valerie Patten and Lucien B. Guze

* Department of Medicine, Harbor General Hospital, Torrance, California 90509
Research and Medical Services, Veterans Administration Hospital (Wadsworth), Los Angeles, California 90073
University of California at Los Angeles School of Medicine, Los Angeles, California 90024

ABSTRACT

The comparative susceptibility of 622 recent clinical isolates of anaerobic bacteria to minocycline, doxycycline, and tetracycline was determined by an agar-dilution technique. In addition to Bacteroides fragilis, a variety of other anaerobic bacteria was resistant to achievable blood concentrations of tetracycline (55% inhibited by 6.25 µg/ml) and doxycycline (58% inhibited by 2.5 µg/ml). In contrast, minocycline was significantly more active (P < 0.05) than both doxycycline and tetracycline, and 70% of strains were inhibited by achievable blood concentrations of this antibiotic (2.5 µg/ml). The enhanced activity of minocycline was particularly striking for Peptococcus asaccharolyticus, P. magnus, P. prevotii, Peptostreptococcus anaerobius, and Bacteroides melaninogenicus. Further evaluation of the clinical efficacy of minocycline against anaerobic infections is indicated.

Antimicrob Agents Chemother. 1975 January; 7(1): 46-49
Copyright © 1975 American Society for Microbiology. All Rights Reserved.



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