This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Klein, R. J. Articles by Friedman-Kien, A. E. Search for Related Content PubMed PubMed Citation Articles by Klein, R. J. Articles by Friedman-Kien, A. E.

 Previous Article  |  Next Article 

Antimicrob Agents Chemother. 1975 March; 7(3): 289-293
Copyright © 1975 American Society for Microbiology. All Rights Reserved.

Phosphonoacetic Acid-Resistant Herpes Simplex Virus Infection in Hairless Mice¹

^a Departments of Microbiology and Dermatology, New York University School of Medicine, New York, New York 10016

ABSTRACT

Phosphonoacetic acid (PAA)-resistant type 1 herpes simplex virus population was isolated by repeated passage of the virus in the presence of this inhibitor. Hairless mice infected percutaneously with the inhibitor-resistant or the parental inhibitor-susceptible virus were treated intraperitoneally with PAA and 9-ß-D-arabinofuranosyl-adenine by using several different dosage schedules. Whereas 9-ß-D-arabinofuranosyl-adenine was effective both in the PAA-susceptible and PAA-resistant herpes simplex virus-induced skin infection, PAA suppressed only the infection induced by the parental PAA-susceptible virus.

¹ Publication 13 from the Cooperative Antiviral Testing Group of the Antiviral Substance Program, Infectious Disease Branch, National Institute of Allergy and Infectious Diseases.