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Antimicrob Agents Chemother. 1975 November; 8(5): 585-590
Copyright © 1975 American Society for Microbiology. All Rights Reserved.

Treatment of Respiratory Klebsiella pneumoniae Infection in Mice with Aerosols of Kanamycin

^a United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21701

ABSTRACT

Aerosols of kanamycin resulted in greater survival of mice challenged with respiratory Klebsiella pneumoniae than the same dosage given intramuscularly. Determinations of viable bacteria in the blood and lungs revealed that aerosolized kanamycin was most effective when infection was confined to the lungs. After the organisms had spread to other areas, however, aerosol therapy was still more effective than intramuscular therapy, but only one-half the infected mice survived.

¹ Present address: Department of Veterinarian Pathology, Washington State University, Pullman, Wash. 99163.

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