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Antimicrob Agents Chemother. 1976 February; 9(2): 224-232
Copyright © 1976 American Society for Microbiology. All Rights Reserved.

Biogenetic Origin of the D-Isoleucine and N-Methyl-L-Alloisoleucine Residues in the Actinomycins

Takehiko Yajima1, Kaarin Mason and Edward Katz

a Department of Microbiology, Georgetown University, Schools of Medicine and Dentistry, Washington, D.C. 20007

ABSTRACT

Studies with 14C-labeled isoleucine stereisomers have established that L-alloisoleucine, D-alloisoleucine, and D-isoleucine may function as precursors for the biogenesis of D-isoleucine and N-methyl-L-alloisoleucine residues in actinomycin. L-[14C]isoleucine appears to be employed chiefly for D-alloisoleucine (and N-methylisoleucine [?] formation); however, its role in the biosynthesis of D-isoleucine and N-methylalloisoleucine remains unclear. The potential pathway of biosynthesis of D-isoleucine and N-methyl-L-isoleucine is discussed.

FOOTNOTES

1 Present address: Microbial Chemistry Research Laboratory, Tanabe Seiyaku Company Ltd., Saitama, Japan.

Antimicrob Agents Chemother. 1976 February; 9(2): 224-232
Copyright © 1976 American Society for Microbiology. All Rights Reserved.





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