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Antimicrob Agents Chemother. 1976 April; 9(4): 569-574
Copyright © 1976 American Society for Microbiology. All Rights Reserved.

Pipemidic Acid: Its Activities Against Various Experimental Infections

Masanao Shimizu, Yoshiyuki Takase, Shinichi Nakamura, Hiromi Katae, Akira Minami, Katsuhisa Nakata and Nobuyuki Kurobe

Research and Development Division, Dainippon Pharmaceutical Co., Ltd., Suita, Osaka, Japan

ABSTRACT

Pipemidic acid, a structural relative of piromidic and nalidixic acids, exhibited substantial therapeutic activity when it was administered orally to mice bearing either widely disseminated or relatively localized infections with Staphylococcus aureus and a variety of gram-negative bacilli. The activity of pipemidic acid was always greater than that of piromidic and nalidixic acids; in infections with Pseudomonas aeruginosa and in bacilli resistant to the latter two drugs, pipemidic acid exhibited significant activity. In limited comparative studies, the activities of pipemidic acid were generally superior to the activities of cephalexin, ampicillin, and carbenicillin. Gentamicin, administered subcutaneously, was more active than pipemidic acid, given either orally or subcutaneously, against both systemic and localized infections with P. aeruginosa. The therapeutic accomplishments of pipemidic acid were attained with well-tolerated doses.

Antimicrob Agents Chemother. 1976 April; 9(4): 569-574
Copyright © 1976 American Society for Microbiology. All Rights Reserved.



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