AAC Accepts, published online ahead of print on 6 April 2009
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Huggins, J.
Right arrow Articles by Hruby, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Huggins, J.
Right arrow Articles by Hruby, D.

 Previous Article  |  Next Article 

Antimicrob. Agents Chemother. doi:10.1128/AAC.00021-09
Copyright (c) 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Non-human primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246

John Huggins, Arthur Goff, Lisa Hensley, Eric Mucker, Josh Shamblin, Carly Wlazlowski, Wendy Johnson, Jennifer Chapman, Tom Larsen, Nancy Twenhafel, Kevin Karem, Inger K. Damon, Chelsea M. Byrd, Tove’ C. Bolken, Robert Jordan, and Dennis Hruby*

US Army Medical Research Institute of Infectious Diseases, Frederick, MD; Centers for Disease Control and Prevention, Atlanta, GA; SIGA Technologies, Corvallis, OR

* To whom correspondence should be addressed. Email: dhruby{at}siga.com.


arrow
Abstract

ST-246, a potent orthopoxvirus egress inhibitor, is safe and effective at preventing disease and death in small animal models challenged by several different pathogenic poxviruses. In this report, the antiviral efficacy of ST-246 was assessed in non-human primates infected with variola virus or monkeypox virus. The data indicates that once per day oral dosing with ST-246 protects animals from poxvirus disease as measured by reduction in viral load, appearance of lesions and survival.




This article has been cited by other articles:

  • Berhanu, A., King, D. S., Mosier, S., Jordan, R., Jones, K. F., Hruby, D. E., Grosenbach, D. W. (2009). ST-246 Inhibits In Vivo Poxvirus Dissemination, Virus Shedding, and Systemic Disease Manifestation. Antimicrob. Agents Chemother. 53: 4999-5009 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»