AAC Accepts, published online ahead of print on 14 April 2008

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Antimicrob. Agents Chemother. doi:10.1128/AAC.00282-08
Copyright (c)2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

First Case of Emergence of Atovaquone-Proguanil (Malarone^TM) Resistance in Plasmodium falciparum During Treatment in Traveller from Comoros

Helene Savini, Hervé Bogreau, Lionel Bertaux, Housem Bouchiba, Philippe Kraemer, Daniel Parzy, Eric Garnotel, Christophe Rogier, Fabrice Simon, and Bruno Pradines^*

Service de Pathologies Infectieuses et Tropicales, Hôpital d'Instruction des Armées Laveran, Marseille, France; Unité de Recherche en Biologie et Epidémiologie Parasitaires, Institut de Médecine Tropicale du Service de Santé des Armées, Marseille, France; Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, Unité mixte de recherche 6236, Marseille, France; Unité de Recherche en Physiologie et Pharmacocinétique Parasitaires, Institut de Médecine Tropicale du Service de Santé des Armées, Marseille, France; Centre National de Référence du Paludisme, Marseille, France; Service de Biologie Médicale, Hôpital d'Instruction des Armées Laveran, Marseille, France

^* To whom correspondence should be addressed. Email: bruno.pradines{at}free.fr.

Malarone^TM (GlaxoSmithKline) is now commonly used for the treatment and prophylaxis of falciparum malaria in France....