In Vitro Susceptibility of Invasive Isolates of Candida Species: Rapid Increase in Rates of Fluconazole Susceptible-Dose Dependent Candida glabrata

Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan; Department of Pharmacology, National Taiwan University Hospital, Taipei, Taiwan; Departments of Internal Medicine, and Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan

^* To whom correspondence should be addressed. Email: hsporen{at}ntu.edu.tw.

	Abstract

Voriconazole, posaconazole, caspofungin, micafungin, and anidulafungin demonstrated potent in vitro activities against 286 invasive Candida isolates. Analysis of fluconazole susceptibility among 204 bloodstream Candida glabrata isolates revealed a rapid trend from susceptible (64% in 1999-2001 and 19% in 2007) to susceptible-dose dependent (27% in 1999-2001 and 75% in 2007).