AAC
Home Help [Feedback] [For Subscribers] [Archive] [Search] --
AAC Accepts, published online ahead of print on 5 May 2008
This Article
Right arrow Full Text (PDF)
Right arrow Other Versions of this Article:
AAC.00492-08v1
52/7/2636    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Google Scholar
Right arrow Articles by Perkhofer, S.
Right arrow Articles by Lass-Flörl, C.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Perkhofer, S.
Right arrow Articles by Lass-Flörl, C.
Antimicrob. Agents Chemother. doi:10.1128/AAC.00492-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Posaconazole Enhances the Activity of Amphotericin B against Zygomycetes Hyphae In Vitro

Susanne Perkhofer*, Maria Locher, Manuel Cuenca-Estrella, Reinhard Rüchel, Reinhard Würzner, Manfred P. Dierich, and Cornelia Lass-Flörl

Department of Hygiene, Microbiology and Social Medicine, Division of Hygiene and Medial Microbiology, Innsbruck Medical University, Innsbruck, Austria; Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain; and Department of Medical Microbiology and National Reference Center for Systemic Mycoses, University Hospital of Göttingen, Göttingen, Germany

* To whom correspondence should be addressed. Email: Susanne.Perkhofer{at}i-med.ac.at.


  Abstract

The in vitro activity of posaconazole plus amphotericin B against conidia and hyphae of 30 clinical zygomycetes was investigated. The combination of posaconazole with amphotericin B was found to be significantly more synergistic (40%) against hyphae (P < 0.05) than conidia (10%). Antagonism was not observed.




Home Help [Feedback] [For Subscribers] [Archive] [Search] --
Clin. Vaccine Immunol. Clin. Microbiol. Rev.
J. Clin. Microbiol. ALL ASM JOURNALS

Copyright © 2008 by the American Society for Microbiology. All rights reserved.