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AAC Accepts, published online ahead of print on 28 April 2008
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AAC.01329-07v1
52/7/2653    most recent
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Antimicrob. Agents Chemother. doi:10.1128/AAC.01329-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Synergy of Human Immunodeficiency Virus Protease Inhibitors with Chloroquine against Plasmodium falciparum in vitro and Plasmodium chabaudi in vivo

Zhengxiang He, Li Qin, Lili Chen, Nanzheng Peng, Jianlan You, and Xiaoping Chen*

Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510663, China

* To whom correspondence should be addressed. Email: chen_xiaoping{at}gibh.ac.cn.


  Abstract

The synergy of the activities between chloroquine and various human immunodeficiency virus protease inhibitors was investigated in chloroquine-resistant and -sensitive malaria parasites. In both in vitro and in vivo assay systems, ritonavir was found to be the most potent in potentiating antimalarial action of chloroquine.




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Copyright © 2008 by the American Society for Microbiology. All rights reserved.