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TABLE 2. Characteristics of isolates of N. gonorrhoeae exhibiting reduced susceptibility to ciprofloxacin

Isolate no.^a Yr of isolation Sex of patient^b Site^c MIC^d (µg/ml) of:
Penicillinase production A/S class^e Country of infection Treatment failure

CIP PEN

990 1989 M U 0.25 >4.0 + NR/IB-1 Philippines NK^f

1075 1989 M U 0.5 0.5 $-$ Pro/IB-1 NK NK

1390^* 1989 M U 0.25 >4.0 + NR/IB-22 Thailand Yes

2678 1991 M R 0.5 >4.0 + Pro/IB-8 Thailand NK

2887 1991 M U 0.25 >4.0 + Pro/IB-14 Australia No

3633 1993 F U 0.5 1.0 $-$ Pro/IB-4 Japan No

3761 1993 M U >0.12 >4.0 + NR/IB-1 NK NK

3767 1993 M U 0.25 0.5 $-$ NR/IB-1 India NK

4300 1995 M U 16.0 >4.0 + Pro/IB-8 Philippines Yes

4482^* 1995 M U 0.5 0.5 $-$ Pro/IB-26 Grand Canary Yes

4688^* 1996 M U 0.5 0.5 $-$ NR/IB-1 Thailand Yes

5218 1997 M U 1.0 0.25 $-$ Pro/IB-7 India No

5259 1997 M U 16.0 0.25 $-$ Pro/IB-18 Thailand NK

5297 1997 F UC 16.0 >4.0 + NR/IB-1 Austria NK

5515 1997 M R 0.5 0.5 $-$ NR/IB-7 NK NK

5532 1997 M U 0.5 1.0 $-$ Pro/IB-1 Sri Lanka NK

5621^* 1997 F U 16.0 0.25 $-$ NR/IB-1 Thailand Yes

5704 1997 M U 0.5 1.0 $-$ Pro/IB-1 NK NK

^a *, two consecutive isolates were taken from each of these patients.

^b M, male; F, female.

^c U, urethra; R, rectum; UC, urethra and cervix.

^d The MIC of nalidixic acid was $>=$ 256 µg/ml for all isolates. CIP, ciprofloxacin; PEN, penicillin.

^e Pro, proline requiring; NR, nonrequiring.

^f NK, not known.

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