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TABLE 3.   EE pharmacokinetic parameters for 12 volunteers

Cycle day and calculation AUC0-12 (ng · h/liter)
 Cmax (ng/liter)
 t1/2 (h)
Cipro-floxacin Placebo Cipro-floxacin Placebo Cipro-floxacin Placebo
11
  Geometric mean 638.85 629.52 100.97 98.92 0.47 11.18
  Geometric SD 1.60 1.49 1.55 1.80 0.45 1.77
  CVa 41.0 64.0 8.3 62.0
16
  Geometric mean 656.17 677.48 108.97 101.68 11.21 10.46
  Geometric SD 1.39 1.48 1.46 1.77 1.75 1.58
  CV 40.0 62.0 48.0
a CV, coefficient of variation.




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