|
|
TABLE 3.
EE pharmacokinetic parameters for 12 volunteers
|
|
| Cycle day and
calculation |
AUC0-12 (ng · h/liter)
|
Cmax
(ng/liter)
|
t1/2 (h)
|
| Cipro-floxacin |
Placebo |
Cipro-floxacin |
Placebo |
Cipro-floxacin |
Placebo
|
|
| 11 |
| Geometric
mean |
638.85 |
629.52 |
100.97 |
98.92 |
0.47 |
11.18
|
| Geometric SD |
1.60 |
1.49 |
1.55 |
1.80 |
0.45 |
1.77
|
| CVa |
|
41.0 |
|
64.0 |
8.3 |
62.0
|
| 16 |
| Geometric
mean |
656.17 |
677.48 |
108.97 |
101.68 |
11.21 |
10.46
|
| Geometric SD |
1.39 |
1.48 |
1.46 |
1.77 |
1.75 |
1.58
|
| CV |
|
40.0 |
|
62.0 |
|
48.0 |
|
|
a
CV, coefficient of variation.
|
|
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