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TABLE 2.   Effects of topical treatment given with various schedules of administration on the development of herpetic cutaneous lesions in infected mice Schedulea Treatmentb AUCc P (compared to the following group)d: a b c d e tid for 4 days starting 24 h postinfection None 33.78 ± 3.89 NS <0.01 <0.01 <0.01 Gel alone 35.23 ± 4.21 NS <0.01 <0.01 <0.01 Gel with 5% ACV 11.60 ± 2.03 <0.01 <0.01 NS NS Acyclovir ointment 10.60 ± 0.28 <0.01 <0.01 NS NS Gel with 3% PFA 15.30 ± 2.88 <0.01 <0.01 NS NS qd for 1 day starting 24 h postinfection None 38.12 ± 4.81 <0.01 NS NS Gel with 5% ACV 20.81 ± 3.97 <0.01 <0.05 NS Acyclovir ointment 32.15 ± 5.71 NS <0.05 NS Gel with 3% PFA 34.75 ± 8.08 NS NS NS tid for 4 days starting 5 days postinfection None 54.00 ± 2.21 NS <0.01 NS NS Gel alone 27.71 ± 8.28 NS <0.05 NS NS Gel with 5% ACV 17.08 ± 4.33 <0.01 <0.05 <0.05 NS Acyclovir ointment 36.17 ± 8.08 NS NS <0.05 NS Gel with 3% PFA 34.20 ± 8.11 NS NS NS NS a tid, three times daily; qd, once daily. b ACV, acyclovir; PFA, foscarnet. c Values are means ± standard errors of the means, calculated as [(score on day 4 + score on day 10)/2] + sum of all scores between day 4 and day 10. d NS, not significant (i.e., P > 0.05). a, infected untreated mice; b, infected mice treated with the gel alone; c, infected mice treated with the gel containing 5% ACV; d, infected mice treated with the acyclovir ointment; e, infected mice treated with the gel containing 3% PFA.

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