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TABLE 1. Demographic and clinical characteristics of the 20 patients in this study

Drug and patient no. Age (yrs) Ht (cm) Wt (kg) Sex^a APACHE II score^b Principal diagnosis^c Infectious diagnosis Outcome

Levofloxacin

  1 34 168 99.9 F 23 Idiopathic thrombocytopenia purpura, respiratory failure Pneumonia Survived

  2 23 170 91.8 F 29 Liver transplant with chronic rejection Pneumonia Survived

  3 48 183 98.0 M 37 End-stage liver disease, acute GI bleeding Pneumonia Died

  4 47 175 95.6 F 28 Pneumococcal sepsis, alcoholic liver disease Pneumonia Died

  5 55 185 80.0 M 26 AAA repair with complications Abdominal surgical wound infection Died

  6 41 163 69.9 M 34 End stage liver disease, acute GI bleeding Pneumonia Died

  7 70 204 125.3 F 29 Sepsis, rhabdomyolysis Cellulitis Survived

  8 46 182 79.4 F 25 Intra-abdominal sepsis Intra-abdominal sepsis Survived

  9 66 173 80.0 M 31 Acetaminophen toxicity, acute liver failure Pneumonia Survived

  10 52 178 83.2 F 35 End stage liver disease, intra-abdominal sepsis Intra-abdominal sepsis Died

Ciprofloxacin

  11 20 162 99.8 M 36 Acute liver failure, sepsis Intra-abdominal sepsis Died

  12 54 182 89.0 M 31 End-stage heart disease Pneumonia Died

  13 48 183 107.4 M 27 End-stage heart disease Pneumonia Died

  14 42 169 88.4 M 25 End-stage liver disease Intra-abdominal sepsis Survived

  15 23 185 91.8 F 18 Liver transplant with chronic rejection Pneumonia Survived

  16 63 173 99.3 M 29 End stage heart disease, cardiogenic shock Pneumonia Survived

  17 73 172 112.7 M 26 Sepsis, ARDS Pneumonia Died

  18 41 178 133.8 M 32 Thoracic aortic dissection Pneumonia Survived

  19 60 170 86.0 F 28 Necrotizing pancreatitis, ARDS Necrotizing pancreatitis Died

  20 59 178 82.2 M 24 End stage liver disease, sepsis Intra-abdominal sepsis Died

^a F, female; M, male.

^b Score on admission to the intensive care unit.

^c AAA, abdominal aortic aneurysm; ARDS, acute respiratory distress syndrome; GI, gastrointestinal.

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