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TABLE 2. Clinical trials of clindamycin plus quinine against P. falciparum malaria

Study details
Regimen
Efficacy (%) Reference

Yr Place Design^b Pop.^c N^d Clindamycin
Quinine
Route^e Days Dosing^f

Dosage, form^a No. of doses/day Dosage No. of doses/day

1974 United States WHO A 5 450 mg, salt 4 540 mg 3 p.o. 3 Yes 100 43

1975 United States WHO A 5 450 mg, salt 3 560 mg 3 p.o. 3 Yes 60 11

1975 United States WHO A 2 600 mg, salt 1 560 mg 3 p.o. 3 No 50 11

1975 Thailand WHO A 4 450 mg, salt 3 540 mg 3 p.o. 3 Yes 100 20

1975 Thailand WHO A 5 150 mg, salt 3 270 mg 3 p.o. 3 No 60 20

1988 Brazil WHO, RCT A 40 10 mg/kg, base 2 12 mg/kg 2 p.o. 3 Yes 90 28

1994 Gabon WHO, RCT C 34 5 mg/kg, base 2 12 mg/kg 2 p.o. 3 Yes 88 32

1995 Gabon WHO, RCT C^g 50 5 mg/kg, base 3 8 mg/kg 3 i.v. 4 Yes 96 31

1995 Gabon WHO, RCT A 40 5 mg/kg, base 2 12 mg/kg 2 p.o. 3^h Yes 92 41

1997 Gabon WHOⁱ C 161 8 mg/kg, salt 2 8 mg/kg 2 p.o. 3 Yes 97 62

2000 Thailand WHO, RCT A 68 5 mg/kg, base 4 8 mg/kg 3 p.o. 7 Yes 100 50

2001 France WHO, RCT A 53 5 mg/kg, salt 3 8 mg/kg 3 i.v. 3 Yes 100 45

2001 Thailand WHO, RCT P 65 5 mg/kg, NS^j 3 8 mg/kg 3 p.o. 7 Yes 100 37

^a Eight milligrams of clindamycin hydrochloride salt is equivalent to 5 mg of base.

^b WHO, study conducted according to World Health Organization guidelines (67); RCT, randomized controlled trial.

^c Pop., study population; A, adults; C, children; P, pregnant women.

^d N, number of subjects.

^e i.v., intravenous; p.o., oral.

^f Adaequate dosing (i.e., clindamycin given at least twice daily and more than 3 days).

^g Severe malaria.

^h Quinine was administered for only 1.5 days.

ⁱ Short follow-up (3 weeks).

^j NS, not specified.

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