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TABLE 1. Drug dosing regimens^a

Sequence Initial Second Third A Levofloxacin, 750 mg once daily, plus metronidazole, 500 mg q8h,b (n = 3) Levofloxacin, 750 mg once daily, plus metronidazole, 1,000 mg once daily (n = 3) Levofloxacin, 750 mg once daily, plus metronidazole, 1,500 mg once daily (n = 3) B Levofloxacin, 750 mg once daily, plus metronidazole, 500 mg q8h (n = 3) Levofloxacin, 750 mg once daily, plus metronidazole, 1,500 mg once daily (n = 3) Levofloxacin, 750 mg once daily, plus metronidazole, 1,000 mg once daily (n = 3) C Levofloxacin, 750 mg once daily, plus metronidazole, 1,000 mg once daily (n = 3) Levofloxacin, 750 mg once daily, plus metronidazole, 1,500 mg once daily (n = 3) Levofloxacin, 750 mg once daily, plus metronidazole, 500 mg q8h (n = 3) D Levofloxacin, 750 mg once daily, plus metronidazole, 1,000 mg once daily (n = 3) Levofloxacin, 750 mg once daily, plus metronidazole, 500 mg q8h (n = 3) Levofloxacin, 750 mg once daily, plus metronidazole, 1,500 once daily (n = 3) E Levofloxacin, 750 mg once daily, plus metronidazole, 1,500 mg once daily (n = 3) Levofloxacin, 750 mg once daily, plus metronidazole, 500 mg q8h (n = 3) Levofloxacin, 750 mg once daily, plus metronidazole, 1,000 mg once daily (n = 3) F Levofloxacin, 750 mg once daily, plus metronidazole, 1,500 mg once daily (n = 3) Levofloxacin, 750 mg once daily, plus metronidazole, 1,000 mg once daily (n = 3) Levofloxacin, 750 mg once daily, plus metronidazole, 500 mg q8h (n = 3)

^a For all sequences, there was a washout period between the initial regimen and the second regimen and between the second regimen and the third regimen.

^b q8h, every 8 h.

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