Return to article

TABLE 1. Drug dosing regimens^a

Sequence Initial Second Third

A Levofloxacin, 750 mg once daily, plus metronidazole, 500 mg q8h,^b (n = 3) Levofloxacin, 750 mg once daily, plus metronidazole, 1,000 mg once daily (n = 3) Levofloxacin, 750 mg once daily, plus metronidazole, 1,500 mg once daily (n = 3)

B Levofloxacin, 750 mg once daily, plus metronidazole, 500 mg q8h (n = 3) Levofloxacin, 750 mg once daily, plus metronidazole, 1,500 mg once daily (n = 3) Levofloxacin, 750 mg once daily, plus metronidazole, 1,000 mg once daily (n = 3)

C Levofloxacin, 750 mg once daily, plus metronidazole, 1,000 mg once daily (n = 3) Levofloxacin, 750 mg once daily, plus metronidazole, 1,500 mg once daily (n = 3) Levofloxacin, 750 mg once daily, plus metronidazole, 500 mg q8h (n = 3)

D Levofloxacin, 750 mg once daily, plus metronidazole, 1,000 mg once daily (n = 3) Levofloxacin, 750 mg once daily, plus metronidazole, 500 mg q8h (n = 3) Levofloxacin, 750 mg once daily, plus metronidazole, 1,500 once daily (n = 3)

E Levofloxacin, 750 mg once daily, plus metronidazole, 1,500 mg once daily (n = 3) Levofloxacin, 750 mg once daily, plus metronidazole, 500 mg q8h (n = 3) Levofloxacin, 750 mg once daily, plus metronidazole, 1,000 mg once daily (n = 3)

F Levofloxacin, 750 mg once daily, plus metronidazole, 1,500 mg once daily (n = 3) Levofloxacin, 750 mg once daily, plus metronidazole, 1,000 mg once daily (n = 3) Levofloxacin, 750 mg once daily, plus metronidazole, 500 mg q8h (n = 3)

^a For all sequences, there was a washout period between the initial regimen and the second regimen and between the second regimen and the third regimen.

^b q8h, every 8 h.

Return to article