Return to article

TABLE 1. Treatment efficacy of sustained-release doxycycline hyclate by subcutaneous injection versus oral administration of doxycycline hyclate^a

Treatment or control No. of mice infected/total no. testedb Level of protection (%)c Oral doxycycline hyclate 7/13 43 Water control 15/16 NA Sustained-release doxycycline hyclate 0/12 100 Copolymer controld 10/12 NA

^a Mice received either a single oral dose of 2 mg of doxycycline hyclate or a single subcutaneous injection of 4.2 mg of sustained-release doxycycline hyclate 72 h after tick infestation. Cultures of ear biopsies were taken 4 weeks postinfestation; bladder and heart tissues were cultured 8 weeks postinfestation.

^b Fisher's test results were as follows: for values for the oral doxycycline hyclate treatment compared with those for the water control treatment, P was 0.02; for values for the sustained-release doxycycline hyclate treatment compared with those for the copolymer control treatment, P was 0.0001; for values for the sustained-release doxycycline hyclate treatment compared with those for the oral doxycycline hyclate treatment, P was 0.005; and for values for the water control treatment compared with those for the copolymer control treatment, P was 0.56.

^c NA, not applicable.

^d Poly(DL-lactide) in N-methyl-2-pyrrolidone was used as the copolymer control.

Return to article