	Help viewing high resolution images
	Return to article

Click on image to view larger version.

FIG. 1. Interactions between HRV 2 3C protease and rupintrivir. All amino acid residues having side chains interacting directly with the bound inhibitor are included (Phe 25, His 40, Glu 71, Ile 125, Leu 127, Ser 128, Asn 130, Thr 142, Cys 147, His 161, Gly 163, Gly 164, Asn 165, and Phe 170). Amino acid residues (Ser 144, Gly 145, and Val 162) having only polypeptide main chain interactions are shown. Other amino acid residues (Asn 22, Gly 23, Lys 24, Leu 126, Lys 143, and Tyr 146) having only polypeptide main chain interactions are not shown. Hydrogen bonds are indicated by dashed lines. The covalent bond between the sulfur ${gamma}$ atom (SG) of Cys 147 and carbon 19 atom (C19) of the inhibitor is shown by a solid line. The drawing was prepared by using the program LIGPLOT (60).

Return to article