Author's Correction for Jullien et al., Antimicrob. Agents Chemother. 49 (8) 3361-3366.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jullien, V.
Right arrow Articles by Urien, S.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Jullien, V.
Right arrow Articles by Urien, S.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, February 2008, p. 808, Vol. 52, No. 2
0066-4804/08/$08.00+0     doi:10.1128/AAC.01423-07

AUTHOR'S CORRECTION

Population Pharmacokinetics of Tenofovir in Human Immunodeficiency Virus-Infected Patients Taking Highly Active Antiretroviral Therapy

Vincent Jullien, Jean-Marc Tréluyer, Elisabeth Rey, Patrick Jaffray, Anne Krivine, Laurence Moachon, Agnès Lillo-Le Louet, Anne Lescoat, Nicolas Dupin, Dominique Salmon, Gérard Pons, and Saïk Urien

Université Paris-Descartes, Faculté de Médecine, Assistance Publique-Hôpitaux de Paris, Pharmacologie Clinique, Biochimie A, Virologie, Dermatologie-Vénérologie, and Médecine Interne, Groupe Hospitalier Cochin-Saint-Vincent-de-Paul, 82 Avenue Denfert-Rochereau, 75674 Paris Cedex 14, France; Pharmacologie Clinique, Hôpital Européen Georges Pompidou, 20 rue Leblanc, 75908 Paris Cedex 15, France; and Institut National de la Santé et de la Recherche Médicale, 101 rue de Tolbiac, 75654 Paris Cedex 13, France

Volume 49, no. 8, p. 3361-3366. The tenofovir dose should be 136 mg instead of 245 mg. The incorrect dose resulted in an overestimation of tenofovir pharmacokinetic parameters. However, it does not have any effect on either covariate-related or variability parameters or on the precision of the estimates, which are dose-independent parameters. Using the correct dose, the mean-weight-normalized CL/F is calculated to be 750 ml/h/kg, which is in the range of the previously described values of 510 to 910 ml/h/kg (P. Barditch-Crovo, S. G. Deeks, A. Collier, S. Safrin, D. F. Coakley, M. Miller, B. P. Kearney, R. L. Coleman, P. D. Lamy, J. O. Khan, I. McGowan, and P. S. Lietman, Antimicrob. Agents Chemother. 45:2733-2739, 2001). The individual AUC and trough concentration values were also unchanged, as the decrease in tenofovir dose was balanced by the decrease in pharmacokinetic parameters so that the relationship found between the AUC and the body weight/serum creatinine ratio and the possible need to change tenofovir dose with respect to this ratio remains valid. The corrected values are listed below.

Page 3361, Abstract, line 6: The Vc/F, Vp/F, Q/F, and CL/F values ± standard errors should read "297 ± 28.5 liters, 848 ± 209 liters, 80 ± 15 liters/h, and 50.5 ± 3.1 liters/h," respectively.

Page 3361, column 2, line 4: The tenofovir dose should be "136 mg."

Page 3363, Table 3: For the final model with the original dataset, the mean values and standard errors should be 50.5 and 3.1 liters/h, respectively, for the CL/F typical value (TV), 297 and 28.5 liters for the Vc/F TV, 80 and 15 liters/h for the Q/F TV, and 848 and 209 liters for the Vp/F TV.

Page 3363, column 2, line 2: "90.9" should read "50.5."

Page 3364, column 1, line 20: "90.9" should read "50.5."

Page 3364, column 2, line 2: "90.9" should read "50.5."

Antimicrobial Agents and Chemotherapy, February 2008, p. 808, Vol. 52, No. 2
0066-4804/08/$08.00+0     doi:10.1128/AAC.01423-07





This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jullien, V.
Right arrow Articles by Urien, S.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Jullien, V.
Right arrow Articles by Urien, S.

Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»