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Mutagenesis in the {alpha}3{alpha}4 GyrA Helix and in the Toprim Domain of GyrB Refines the Contribution of Mycobacterium tuberculosis DNA Gyrase to Intrinsic Resistance to Quinolones
Antimicrob. Agents Chemother. Matrat et al. 52: 2909

Supplemental material

Files in this Data Supplement:

  • Supplemental file 1 - Fig. S1, SDS-PAGE of purified altered recombinant subunits of M. tuberculosis DNA gyrase; Fig. S2, representative assay for ofloxacin-mediated DNA cleavage; and Fig. S3, DNA cleavage promoted by enoxacin and nalidixic acid for wild-type M. tuberculosis DNA gyrase.
    Zipped MS Word document, 749K.



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