This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by De Nollin, S.
Right arrow Articles by Borgers, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by De Nollin, S.
Right arrow Articles by Borgers, M.

 Previous Article  |  Next Article 

Antimicrob Agents Chemother. 1977 March; 11(3): 500-513
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Cytochemical and Biochemical Studies of Yeasts After In Vitro Exposure to Miconazole

Sonja De Nollin, H. Van Belle, F. Goossens, F. Thone and M. Borgers

Laboratories of Cell Biology and Biochemistry, Janssen Pharmaceutica, Research Laboratories, 2340 Beerse, Belgium

ABSTRACT

Yeast cells exposed to different doses of the antimycotic agent miconazole revealed important cytochemical changes in the topographic distribution of the phosphatases. A strong effect was observed on the behavior of oxidative and peroxidative enzymes. Decreased cytochrome c oxidase and peroxidase activity and increased catalase activity were seen after treatment with a fungistatic dose of miconazole, whereas a complete disappearance of these enzymes was observed after treatment with a minimal fungicidal dose of miconazole. This was in complete agreement with the quantitative biochemical data. A hypothesis is advanced concerning the possible involvement of peroxidase and catalase in the mechanism of action of this drug.

Antimicrob Agents Chemother. 1977 March; 11(3): 500-513
Copyright © 1977 American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Francois, I. E. J. A., Bink, A., Vandercappellen, J., Ayscough, K. R., Toulmay, A., Schneiter, R., van Gyseghem, E., Van den Mooter, G., Borgers, M., Vandenbosch, D., Coenye, T., Cammue, B. P. A., Thevissen, K. (2009). Membrane Rafts Are Involved in Intracellular Miconazole Accumulation in Yeast Cells. J. Biol. Chem. 284: 32680-32685 [Abstract] [Full Text]  
  • Trivedi, V., Chand, P., Srivastava, K., Puri, S. K., Maulik, P. R., Bandyopadhyay, U. (2005). Clotrimazole Inhibits Hemoperoxidase of Plasmodium falciparum and Induces Oxidative Stress: PROPOSED ANTIMALARIAL MECHANISM OF CLOTRIMAZOLE. J. Biol. Chem. 280: 41129-41136 [Abstract] [Full Text]  
  • Helmick, R. A., Fletcher, A. E., Gardner, A. M., Gessner, C. R., Hvitved, A. N., Gustin, M. C., Gardner, P. R. (2005). Imidazole Antibiotics Inhibit the Nitric Oxide Dioxygenase Function of Microbial Flavohemoglobin. Antimicrob. Agents Chemother. 49: 1837-1843 [Abstract] [Full Text]  
  • Liao, R. S., Rennie, R. P., Talbot, J. A. (2003). Sublethal Injury and Resuscitation of Candida albicans after Amphotericin B Treatment. Antimicrob. Agents Chemother. 47: 1200-1206 [Abstract] [Full Text]  
  • Tiffert, T., Ginsburg, H., Krugliak, M., Elford, B. C., Lew, V. L. (2000). Potent antimalarial activity of clotrimazole in in vitro cultures of Plasmodium falciparum. Proc. Natl. Acad. Sci. USA 97: 331-336 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»