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Antimicrob Agents Chemother. 1979 August; 16(2): 186-189
Copyright © 1979, American Society for Microbiology. All Rights Reserved.

Antibiotic Susceptibility of Haemophilus vaginalis (Corynebacterium vaginale) to 21 Antibiotics

Laurence R. McCarthy, Patricia A. Mickelsen and E. Grover Smith{dagger}

1 Department of Hospital Laboratories, North Carolina Memorial Hospital, and Department of Bacteriology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27514

ABSTRACT

A total of 56 strains of Haemophilus vaginalis were tested for their in vitro susceptibility to 21 antimicrobial agents by an agar dilution method. All strains were inhibited by 1 µg or less of penicillin, ampicillin, carbenicillin, and vancomycin per ml. The cephalosporins were less active; 4 µg of cefazolin per ml, 16 µg of cephalothin per ml, or 128 µg of cephalexin per ml was required to inhibit all strains. Kanamycin, gentamicin, tobramycin, and neomycin were relatively inactive against H. vaginalis. All strains were inhibited by 4 µg of streptomycin per ml and 2 µg of chloramphenicol per ml. Only 57% of the strains were inhibited by 4 µg of tetracycline per ml, whereas 43% were inhibited by 16 to 64 µg/ml. The combination sulfamethoxazole/trimethoprim was relatively inactive against H. vaginalis. All strains tested exhibited minimal inhibitory concentrations of ≥128 µg when tested against colistin, nalidixic acid, and sulfadiazine. Erythromycin and clindamycin were the most active of the antibiotics tested; for all strains the minimal inhibitory concentrations were ≤0.06 µg/ml.

FOOTNOTES

{dagger} Present address: Department of Pathology, Wake County Medical Center, Raleigh, NC 27610.

Antimicrob Agents Chemother. 1979 August; 16(2): 186-189
Copyright © 1979, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Muli, F., Struthers, J. K. (1998). Use of a Continuous-Culture Biofilm System To Study the Antimicrobial Susceptibilities of Gardnerella vaginalis and Lactobacillus acidophilus. Antimicrob. Agents Chemother. 42: 1428-1432 [Abstract] [Full Text]  


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