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Antimicrob Agents Chemother. 1979 August; 16(2): 217-220
Copyright © 1979, American Society for Microbiology. All Rights Reserved.

In Vitro Susceptibilities of Naegleria fowleri Strain HB-1 to Selected Antimicrobial Agents, Singly and in Combination

Kenneth K. Lee1, Stephen L. Karr Jr.2, Ming M. Wong3 and Paul D. Hoeprich1

1 Section of Infectious Diseases, University of California–Davis Medical Center, University of California, Davis, California 95616
2 California Primate Research Center, University of California, Davis, California 95616
3 Department of Veterinary Microbiology, University of California, Davis, California 95616

ABSTRACT

The overall prognosis of primary amoebic meningoencephalitis remains poor. The results of this study support previous finding that amphotericin B is the most efficacious drug against the Naegleria species in in vitro testing. In addition, the methyl ester of amphotericin B, a new derivative, also appears to be an effective agent. Of the drug combinations studied, amphotericin B plus minocycline and amphotericin B plus tetracycline showed synergy. The clinical significance of these findings remains to be determined.

Antimicrob Agents Chemother. 1979 August; 16(2): 217-220
Copyright © 1979, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Soltow, S. M., Brenner, G. M. (2007). Synergistic Activities of Azithromycin and Amphotericin B against Naegleria fowleri In Vitro and in a Mouse Model of Primary Amebic Meningoencephalitis. Antimicrob. Agents Chemother. 51: 23-27 [Abstract] [Full Text]  
  • Goswick, S. M., Brenner, G. M. (2003). Activities of Azithromycin and Amphotericin B against Naegleria fowleri In Vitro and in a Mouse Model of Primary Amebic Meningoencephalitis. Antimicrob. Agents Chemother. 47: 524-528 [Abstract] [Full Text]  


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