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Antimicrob Agents Chemother. 1982 March; 21(3): 421-425

Cefotaxime therapy of serious bacterial infection in adults.

D T Mullaney and J F John Jr

ABSTRACT

We evaluated the efficacy, safety, and tolerance of cefotaxime in 35 adults (25 with pleuropulmonary infections, 7 with genitourinary tract infections, and 3 with soft tissue infections). Of these 35 patients, 18 (51.4%) were seriously or critically ill. In vitro susceptibility testing revealed that 90.4% of the pathogens isolated were susceptible to cefotaxime (minimal inhibitory concentration, less than 8 micrograms/ml), 4.8% were intermediately susceptible (minimal inhibitory concentration, 8 to 32 micrograms/ml), and 4.8% were resistant (minimal inhibitory concentration, greater than 32 micrograms/ml). A total of 34 of the 35 patients (97%) were clinically and bacteriologically cured of their infections. Adverse reactions occurred in two patients, but these reactions did not require interruption of therapy.

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Antimicrob Agents Chemother. 1982 March; 21(3): 421-425

This article has been cited by other articles:

• Mullaney, D. T., John, J. F. (1983). Cefotaxime Therapy: Evaluation of Its Effect on Bacterial Meningitis, CSF Drug Levels, and Bactericidal Activity. Arch Intern Med 143: 1705-1708 [Abstract]