This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Stevens, D A Articles by Vo, P T Search for Related Content PubMed PubMed Citation Articles by Stevens, D A Articles by Vo, P T

 Previous Article  |  Next Article 

Antimicrob Agents Chemother. 1982 May; 21(5): 852-854

Synergistic interaction of trimethoprim and sulfamethoxazole on Paracoccidioides brasiliensis.

D A Stevens and P T Vo

ABSTRACT

The in vitro interaction of trimethoprim and sulfamethoxazole on clinical isolates of Paracoccidioides brasiliensis was studied. With complete inhibition and a visual endpoint used as the criteria, three of four strains had minimal inhibitory concentrations that indicated resistance to sulfamethoxazole, and all four strains were resistant to trimethoprim. A marked synergism in inhibition was noted with the combination of these drugs against sulfa-resistant strains. A sulfamethoxazole/trimethoprim ratio of 5:1 was the most synergistic. Fifty percent inhibition, determined spectrophotometrically, of the strains could be achieved with sulfamethoxazole alone. In summary, the striking synergy observed suggests that combination chemotherapy with these drugs deserves further study.

---

Antimicrob Agents Chemother. 1982 May; 21(5): 852-854

This article has been cited by other articles:

• Afeltra, J., Meis, J. F. G. M., Vitale, R. G., Mouton, J. W., Verweij, P. E. (2002). In Vitro Activities of Pentamidine, Pyrimethamine, Trimethoprim, and Sulfonamides against Aspergillus Species. Antimicrob. Agents Chemother. 46: 2029-2031 [Abstract] [Full Text]  
• Stevens, D. A. (2000). Drug Interaction Studies of a Glucan Synthase Inhibitor (LY 303366) and a Chitin Synthase Inhibitor (Nikkomycin Z) for Inhibition and Killing of Fungal Pathogens. Antimicrob. Agents Chemother. 44: 2547-2548 [Abstract] [Full Text]