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Antimicrob Agents Chemother. 1985 April; 27(4): 650-651

Inhibitory effect of cephalosporins on gamma-aminobutyric acid receptor binding in rat synaptic membranes.

S Hori, S Kurioka, M Matsuda and J Shimada

ABSTRACT

Cephalosporins inhibited gamma-aminobutyric acid receptor binding in a concentration-dependent manner in vitro. Scatchard analysis revealed that cefazolin decreased the binding capacity but did not change the affinity of the receptor. It is suggested that this inhibition of gamma-aminobutyric acid receptor binding may be involved in the induction of convulsions by cephalosporins.

Antimicrob Agents Chemother. 1985 April; 27(4): 650-651




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