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Antimicrob Agents Chemother. 1985 April; 27(4): 655-656

Aztreonam therapy in experimental meningitis due to Haemophilus influenzae type b and Escherichia coli K1.

G H McCracken Jr, Y Sakata and K D Olsen

ABSTRACT

The penetration of aztreonam into cerebrospinal fluid was 7 to 15% and 9 to 25%, respectively, in experimental Haemophilus influenzae type b and Escherichia coli K1 meningitis. Aztreonam was effective in reducing the number of organisms in cerebrospinal fluid after single-dose and continuous infusion administration, and the median bactericidal titers in cerebrospinal fluid were 1:32 against both meningeal pathogens.

Antimicrob Agents Chemother. 1985 April; 27(4): 655-656






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