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Antimicrob Agents Chemother. 1985 June; 27(6): 953-957

Inhibition of Chlamydia trachomatis growth in McCoy, HeLa, and human prostate cells by zinc.

S B Greenberg, D Harris, P Giles, R R Martin and R J Wallace Jr

ABSTRACT

Zinc salts (10(-4) and 10(-5) M) inhibited the number of Chlamydia trachomatis inclusions in McCoy, HeLa, and primary human prostate epithelial cell cultures. Addition of zinc salts 1 h before or 24 h after inoculation with C. trachomatis was found to inhibit growth. Both C. trachomatis serotype D and a lymphogranuloma venereum strain were inhibited by the zinc salts. Although the mechanism of inhibition is not known, the continued presence of the zinc appeared necessary for maximal effect. At the concentrations tested, zinc was not directly toxic to the McCoy cells. These results suggest that the levels of zinc in prostatic secretions may be sufficient to preclude the recovery of chlamydia in the diagnostic laboratory or to inhibit chlamydia from infecting the prostate in vivo.

Antimicrob Agents Chemother. 1985 June; 27(6): 953-957




This article has been cited by other articles:

  • Cunningham, K. A., Beagley, K. W. (2008). Male Genital Tract Chlamydial Infection: Implications for Pathology and Infertility. Biol. Reprod. 79: 180-189 [Abstract] [Full Text]  
  • Bourne, N., Stegall, R., Montano, R., Meador, M., Stanberry, L. R., Milligan, G. N. (2005). Efficacy and Toxicity of Zinc Salts as Candidate Topical Microbicides against Vaginal Herpes Simplex Virus Type 2 Infection. Antimicrob. Agents Chemother. 49: 1181-1183 [Abstract] [Full Text]  


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