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Antimicrob Agents Chemother. 1985 June; 27(6): 961-963

Activity of a peptidyl prodrug, alafosfalin, against anaerobic bacteria.

S F Grappel, A J Giovenella and L J Nisbet

ABSTRACT

Alafosfalin, an antibacterial phosphonodipeptide requiring peptide transport for activity, was tested for activity against clinical strains of anaerobic bacteria in peptide-free Roche Sensitivity Test Medium no. 5 agar. It was active against Bacteroides spp., Fusobacterium nucleatum, and Clostridium perfringens but not against Clostridium difficile. Alafosfalin activity was antagonized by appropriate peptides. Synergy was obtained with other cell wall-active antibiotics.

Antimicrob Agents Chemother. 1985 June; 27(6): 961-963






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