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Antimicrob Agents Chemother. 1985 June; 27(6): 985-988

Elimination of multicopy plasmid R6K by bleomycin.

P V Attfield and R J Pinney

ABSTRACT

Bleomycin eliminated multicopy plasmid R6K from growing cells of Escherichia coli AB1157 but failed to cure either of the low-copy plasmids R1 or R46. Measurements of R6K-encoded beta-lactamase and of covalently closed plasmid DNA indicated that the drug causes a progressive reduction in plasmid copy number.

Antimicrob Agents Chemother. 1985 June; 27(6): 985-988






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