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Antimicrob Agents Chemother. 1973 February; 3(2): 181-187
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

DD-Carboxypeptidase-Transpeptidase and Killing Site of ß-Lactam Antibiotics in Streptomyces Strains R39, R61, and K11

Jean Dusart, Alberto Marquet, Jean-Marie Ghuysen, Jean-Marie Frère, Ramon Moreno, Melina Leyh-Bouille, Kenneth Johnson1, Chantal Lucchi, Harold R. Perkins and Manuel Nieto

Service de Microbiologie, Faculté de Médecine, Institut de Botanique, Université de Liège, Sart-Tilman, 4000 Liège, Belgium
National Institute for Medical Research, Mill Hill, London, England
Centro de Investigaciones Biologicas, Instituto de Biologia Celular, Madrid, Spain

ABSTRACT

Additional evidence is given that in Streptomyces strains R39, R61, and K11 the same enzyme performs DD-carboxypeptidase and transpeptidase activities and that this enzyme is the killing site of ß-lactam antibiotics. With strain R61, it was found that the exocellular enzyme has a sensitivity towards some antibiotics different from that of the membrane-bound enzyme. Under the growth conditions used in the present investigations, ß-lactamase activity was not involved in susceptibility to ß-lactam antibiotics.

FOOTNOTES

1 Permanent address: Division of Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada.

Antimicrob Agents Chemother. 1973 February; 3(2): 181-187
Copyright © 1973 American Society for Microbiology. All Rights Reserved.





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