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Antimicrob Agents Chemother. 1973 February; 3(2): 198-206
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

Studies on the Toxicity and Antiviral Activity of Various Polynucleotides1

D. R. Black2, F. Eckstein, E. DeClercq3 and T. C. Merigan

Division of Infectious Diseases, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305
Division of Chemistry, Max-Planck Institute for Experimental Medicine, Göttingen, West Germany

ABSTRACT

Various polynucleotides were examined for antiviral activity and toxicity in mice. Although the antiviral potency of the various interferon inducers varied, there was a concomitant variation in toxicity. This was reflected by a fivefold range in therapeutic ratio for the various compounds. In addition, no polynucleotide proved to be a more potent interferon inducer than polyinosinic·polycytidylic acid [(poly rI)·(poly rC)]. Our results suggest that there may be intrinsic limitations to the development of polynucleotide interferon inducers having improved therapeutic ratios.

FOOTNOTES

2 Present address: Division of Life Sciences, Stanford Research Institute, Menlo Park, Calif. 94025.

3 Present address: Rega Institute, Catholic University of Louvain, Louvain, Belgium.

1 A summary of this work was presented at the 72nd Annual Meeting of the American Society for Microbiology, Philadelphia, Pa., 24 April 1972.

Antimicrob Agents Chemother. 1973 February; 3(2): 198-206
Copyright © 1973 American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Carter, W. A., De Clercq, E. (1974). Viral Infection and Host Defense. Science 186: 1172-1178 [Abstract]  


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