This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by James, A Articles by Prober, C Search for Related Content PubMed PubMed Citation Articles by James, A Articles by Prober, C

 Previous Article  |  Next Article 

Antimicrob Agents Chemother. 1987 January; 31(1): 52-54

Vancomycin pharmacokinetics and dose recommendations for preterm infants.

A James, G Koren, J Milliken, S Soldin and C Prober

ABSTRACT

The pharmacokinetics of intravenous vancomycin was studied in 20 preterm infants (gestational age, 26.5 weeks +/- 2.6 weeks [standard deviation]; birthweight, 880 +/- 340 g). At the time of the studies their postconceptional age was 36.4 +/- 4.5 weeks. The drug was infused over 30 min in a dose between 9.2 and 18 mg/kg. A highly significant correlation existed between postconceptional age or body weight and vancomycin t1/2 and clearance. Serum creatinine concentrations correlated with vancomycin t1/2 and clearance. Serum creatinine tended to decrease with increasing postconceptional age. Based on the excellent correlation between age (or weight) and vancomycin pharmacokinetics, dose and dose-interval recommendations are presented.

---

Antimicrob Agents Chemother. 1987 January; 31(1): 52-54

This article has been cited by other articles:

• Plan, O, Cambonie, G, Barbotte, E, Meyer, P, Devine, C, Milesi, C, Pidoux, O, Badr, M, Picaud, J C (2008). Continuous-infusion vancomycin therapy for preterm neonates with suspected or documented Gram-positive infections: a new dosage schedule. Arch. Dis. Child. Fetal Neonatal Ed. 93: F418-F421 [Abstract] [Full Text]  
• Tan, W-H, Brown, N, Kelsall, A W, McClure, R J (2002). Dose regimen for vancomycin not needing serum peak levels?. Arch. Dis. Child. Fetal Neonatal Ed. 87: F214-216 [Abstract] [Full Text]  
• Bhatt-Mehta, V., Schumacher, R. E., Faix, R. G., Leady, M., Brenner, T. (1999). Lack of Vancomycin-associated Nephrotoxicity in Newborn Infants: A Case-Control Study. Pediatrics 103: 48e-48 [Abstract] [Full Text]