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Antimicrob Agents Chemother. 1989 August; 33(8): 1375-1378

Continuous infusion of high-dose acyclovir for serious herpesvirus infections.

C V Fletcher, J A Englund, B Bean, B Chinnock, D M Brundage and H H Balfour Jr

Department of Pharmacy Practice, University of Minnesota, Health Sciences Center, Minneapolis 55455.

ABSTRACT

Thirteen patients with herpesvirus infections who were unresponsive to at least 72 h of intermittent acyclovir administration received high-dose continuous infusion. Steady-state concentrations were maintained at between 20 and 98 mumol/liter. Of 12 patients who had continuous infusion for greater than 5 days, 7 (58%) resolved their infections, as determined by clinical and virologic parameters, suggesting that continuous infusion may succeed in some patients who do not respond to conventional therapy.

Antimicrob Agents Chemother. 1989 August; 33(8): 1375-1378




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